A church has stood at Multrå since medieval times. Sources agree an early wooden church likely existed by the 1200s or 1300s, with local tradition recording a visit from the Archbishop of Uppsala in 1314, though this date is not independently confirmed. According to a local legend, a stone church was later built in the 15th century by five neighbouring farmers, replacing the timber building.
That medieval stone church proved too small more than once. Following the depredations of Gustav Vasa's bell levy, which removed three of the four church bells and other valuables, the parish grew poorer. By the mid-1600s the building was dilapidated and cramped, prompting an extension between the 1750s and 1770s that roughly doubled its size and allowed for a separate bell tower. The Baroque pulpit from the 1600s and a medieval saint's cabinet were retained from the earlier building; both were later transferred to a museum in Härnösand.
By the early 19th century the growing congregation had once again outgrown the church. Plans for a shared church with Sollefteå were considered but abandoned in favour of a new building for Multrå alone. Construction of the present stone church, in the neoclassical style sometimes called Karl Johan style, began in 1862 (or 1863, according to differing accounts) and was completed by 1867–68; it was consecrated in June 1869 and could seat around 480 people. The older stone church was not demolished entirely — part of it survives, incorporated into the present building as the sacristy.
Inside, the altarpiece of 1769, by Johan Edler the Elder, is regarded as the church's finest decorative feature. The font dates from 1922, and the organ and its case were made in 1965 by Grönlunds Orgelbyggeri. Of the two bells in the tower, the smaller is said to date from medieval times, though it was recast in 1735. The church has undergone restoration work in the 20th century, including in 1914 and 1957, and again in 2006.