Construction began around 1272–1273 under an anonymous French master mason, continuing under Étienne de Bonneuil from 1287. Built largely in brick with limestone detailing, the cathedral follows a French Gothic basilica plan and was consecrated in 1435, though work on the west towers continued into the following century. Fires in 1447, 1572 and a devastating blaze in 1702 repeatedly damaged the building and destroyed most of its furnishings, leading to phases of rebuilding in Baroque style during the eighteenth century.
The cathedral's present appearance owes much to a large-scale restoration led by Helgo Zettervall between 1885 and 1893, which aimed to unify the building's character around its French Gothic origins. Zettervall's team rebuilt the west front and much of the exterior cladding, raised the towers to their current height and gave them their distinctive spires. The choice of cement rather than stone for exterior details proved problematic, causing decades of weathering issues that required further conservation work well into the twentieth century, and a further restoration took place in the 1970s.
Uppsala domkyrka has long served as a national shrine. From 1441 to 1719, all but three Swedish monarchs were crowned here, and the church holds the tomb of King Gustav Vasa together with his queens, as well as monuments to King Johan III. The scientist Carl von Linné (Linnaeus) is also buried within the cathedral, along with several archbishops, including Nathan Söderblom, who won the Nobel Peace Prize.//A shrine associated with Saint Erik, a locally venerated medieval king regarded as Uppsala's patron saint despite never being formally canonised, is kept in the Finsta choir, along with a modern reliquary said to contain a fragment of Saint Bridget's remains.
Among the cathedral's furnishings, the large Baroque pulpit by Burchard Precht, presented after the 1702 fire and designed by Nicodemus Tessin the Younger, remains in use for Sunday services. The Sture choir recalls a violent episode in Swedish history: members of the aristocratic Sture family were murdered on the orders of King Erik XIV in 1567, and clothing said to have been worn at the time is kept in the cathedral's treasury museum. The cathedral's textile collection spans from the thirteenth century to the present, and its organs, including a nineteenth-century instrument by Per Larsson Åkerman recently restored, continue to be used for concerts and services.